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Weeks 1 to 4: the GI phase During the initial weeks, particularly during the 0.25 mg starting dose and the first escalation to 0.5 mg, GI side effects dominate

[14] [15] Other statins such as simvastatin, pravastatin, and rosuvastatin may be used based on individual patient factors, tolerability, and cost-effectiveness considerations

Clinical judgment is essential

The total weekly dose remains identical, but the peaks and troughs of drug concentration are smaller

The price stays the same at every dose, and for an uninsured shopper planning to titrate up, that is the one variable that most often decides your real annual cost